| National Philanthropic Tr | Jenkintown | $17,794,939,562 |
| Donor Advised Charitable Giving | Lone Tree | $11,676,597,614 |
| Gates Foundation | Seattle | $7,810,137,842 |
| Vanguard Charitable Endowment Program | Malvern | $6,666,887,642 |
| Gs Donor Advised Philanthropy Fund for Wealth Management Inc | New York | $6,592,899,306 |
| Gates Foundation Trust | Kirkland | $6,534,759,844 |
| Silicon Valley Community Foundation | Mountain View | $4,889,245,872 |
| Michael & Susan Dell Foundation | Austin | $4,322,649,164 |
| National Christian Charitable Foundation | Alpharetta | $3,300,091,756 |
| Morgan Stanley Global Impact Funding Trust Inc | Westfield | $3,082,075,235 |
| A D F Community Outreach Foundation Inc | Mechanicsvlle | $2,878,868,000 |
| American Online Giving Foundation Inc | Newark | $2,503,754,849 |
| Renaissance Charitable Foundation Inc | Indianapolis | $2,436,033,430 |
| Good Ventures Foundation | Palo Alto | $2,206,469,589 |
| The Chicago Community Trust | Chicago | $2,143,553,763 |
| Merck Patient Assistance Program Inc | Rahway | $1,952,689,147 |
| American Endowment Foundation | Hudson | $1,891,313,285 |
| Knight Foundation | Beaverton | $1,730,391,596 |
| Bank of America Charitable Gift Fund | Boston | $1,664,401,095 |
| Bloomberg Family Foundation Inc | New York | $1,514,801,871 |
| Jewish Communal Fund | New York | $1,337,028,835 |
| The Susan Thompson Buffett Foundation | Omaha | $1,270,458,581 |
| Volkswagen-Stiftung | Salt Lake Cty | $1,179,927,202 |
| Charities Aid Foundation America | Alexandria | $1,059,508,784 |
| Signatry Charitable Trust | Sioux Falls | $1,038,691,653 |
| Raymond James Charitable Endowment Fund | St Petersburg | $955,087,502 |
| Jack Joseph and Morton Mandel Foundation | Cleveland | $929,693,588 |
| Glaxosmithkline Patient Access Programs Foundation | Philadelphia | $902,976,608 |
| Robert Wood Johnson Foundation | Princeton | $898,458,824 |
| Walton Family Foundation Inc | Bentonville | $872,237,914 |
| Foundation to Promote Open Society | New York | $842,821,637 |
| Paypal Charitable Giving Fund | Washington | $813,412,937 |
| Greater Kansas City Community Foundation | Kansas City | $781,787,887 |
| Adam R Scripps Foundation | Ft Mitchell | $767,188,798 |
| Walter Scott Family Foundation | Omaha | $762,474,726 |
| Foundation for the Carolinas | Charlotte | $761,389,623 |
| Greater Horizons | Kansas City | $754,144,636 |
| Rockefeller Philanthropy Advisors Inc | New York | $706,026,148 |
| Laura and John Arnold Foundation | Houston | $687,258,876 |
| Impactassets Inc | Bethesda | $680,266,004 |
| Lettie Pate Evans Foundation Inc Trustee of the Restricted Fund Uw | Atlanta | $665,581,251 |
| Donors Fund Inc | Lakewood | $663,839,363 |
| Leona M & Harry B Helmsley Charitable Trust | New York | $629,133,449 |
| John D & Catherine T Macarthur Foundation | Chicago | $613,786,298 |
| William & Flora Hewlett Foundation | Menlo Park | $602,064,005 |
| Haplotace Foundation | Birmingham | $560,704,469 |
| George Kaiser Family Foundation | Tulsa | $549,695,640 |
| The Blackbaud Giving Fund | Daniel Island | $545,823,387 |
| Apella Health Management Inc | Spartanburg | $524,676,090 |
| Builders Initiative | Chicago | $519,855,780 |