| National Philanthropic Tr | Jenkintown | $17,794,939,562 |
| Vanguard Charitable Endowment Program | Malvern | $6,666,887,642 |
| Glaxosmithkline Patient Access Programs Foundation | Philadelphia | $902,976,608 |
| John Templeton Foundation | West Conshohocken | $175,754,080 |
| The Pittsburgh Foundation | Pittsburgh | $159,126,734 |
| High Foundation | Lancaster | $118,776,589 |
| Dietrich Foundation | Pittsburgh | $107,295,535 |
| The Heinz Endowments | Pittsburgh | $93,890,340 |
| Philadelphia Foundation | Philadelphia | $88,851,245 |
| Jewish Federation of Greater Pittsburgh | Pittsburgh | $79,693,583 |
| Jewish Federation of Greater Philadelphia | Philadelphia | $76,883,429 |
| Longwood Gardens Inc | Kennett Square | $72,037,073 |
| The James Family Charitable Trust | Jenkintown | $69,568,941 |
| Scott Foundation Inc | Greensburg | $66,502,643 |
| Fund for Charitable Giving | Pittsburgh | $54,953,090 |
| Anabaptist Foundation | Lewisburg | $54,275,922 |
| Hamilton Family Charitable Trust | Wayne | $43,913,267 |
| Andrea W and Kenneth C Frazier Family Foundation | Philadelphia | $42,656,774 |
| Louis J Mascaro Foundation Inc | Audubon | $42,197,268 |
| The American Electric Power System Retiree Medical Benefit Trust for | Pittsburgh | $41,059,078 |
| Erie Community Foundation | Erie | $39,773,154 |
| The United Way of Southwestern Pennsylvania | Pittsburgh | $38,540,763 |
| J E Barbey 8 Tenacre Foundation | Pittsburgh | $38,065,169 |
| The Aileen K and Brian L Roberts Foundation | Philadelphia | $36,622,976 |
| Community Foundation of Western Pennsylvania and Eastern Ohio | Sharon | $27,668,592 |
| The Lenfest Inst for Journalism Spe Asset Fund of the Phl Foundation | Philadelphia | $26,054,320 |
| Wyncote Foundation | Philadelphia | $26,044,341 |
| Lancaster County Community Foundation | Lancaster | $23,951,452 |
| Colcom Foundation | Pittsburgh | $23,457,577 |
| The Comcast Nbcuniversal Foundation | Philadelphia | $23,063,253 |
| Neubauer Family Foundation | Philadelphia | $21,431,320 |
| Community Foundation of Greater Johnstown | Johnstown | $20,703,045 |
| York County Community Foundation | York | $19,493,761 |
| United Way of Greater Philadelphia and Southern New Jersey | Philadeplhia | $19,407,958 |
| Dicks Sporting Goods Foundation | Coraopolis | $16,726,802 |
| Donald B and Dorothy L Stabler Foundation | Camp Hill | $15,995,340 |
| Independence Blue Cross Foundation | Philadelphia | $15,536,483 |
| Lor Foundation Inc | West Chester | $14,754,002 |
| I Am Mercy Foundation | Haverford | $13,779,079 |
| Daniel B and Florence E Green Foundation | Conshohocken | $12,132,631 |
| Chubb Charitable Foundation | Philadelphia | $7,389,931 |
| Alexander Grass Foundation | Mechanicsburg | $6,121,389 |
| Leslie Miller and Richard Worley Foundation | Bryn Mawr | $3,445,487 |
| Howmet Aerospace Foundation | Pittsburgh | $3,433,926 |
| Highmark Foundation | Pittsburgh | $2,755,132 |
| Seed the Dream Foundation | Gladwyne | $2,461,342 |
| Maguire Foundation | West Conshohocken | $2,126,507 |