| Bank of America Charitable Gift Fund | Boston | $1,664,401,095 |
| The US Charitable Gift Trust | Boston | $430,857,316 |
| Boston Foundation Inc | Boston | $426,656,046 |
| Combined Jewish Philanthropies of Greater Boston Inc | Boston | $357,344,529 |
| Cummings Foundation Inc | Woburn | $297,491,556 |
| Bny Mellon Charitable Gift Fund | Boston | $284,885,079 |
| Popplestone Foundation | Boston | $194,570,556 |
| Barr Foundation | Boston | $153,286,565 |
| Jeremy and Hannelore Grantham Environmental Trust | Boston | $74,664,584 |
| Klarman Family Foundation | Boston | $72,505,265 |
| Jerome Lyle Rappaport Charitable Foundation | Burlington | $65,459,767 |
| The Morningside Foundation | Newton Centre | $64,265,308 |
| Fiduciary Charitable Foundation | Boston | $61,054,716 |
| one8 Foundation | Boston | $52,544,456 |
| Champions of Love Foundation Inc | Boston | $49,058,977 |
| Liberty Mutual Foundation Inc | Boston | $46,323,148 |
| Adelson Family Foundation | Needham | $45,022,474 |
| United Way of Massachusetts Bay Inc | Boston | $41,381,335 |
| The Grantham Foundation for the Protection of the Environment | Boston | $39,985,210 |
| Micah Philanthropies | Agawam | $38,352,127 |
| Dr Miriam and Sheldon G Adelson Medical Research Foundation | Needham | $37,618,546 |
| Community Foundation of Western Massachusetts | Springfield | $37,101,884 |
| Cummings Foundation Grants Inc | Woburn | $35,218,088 |
| The Jaket Foundation | Boston | $30,326,216 |
| The Robert and Michelle Cooke Atchinson Foundation | Winchester | $29,614,165 |
| Growald Climate Fund Inc | Brookline | $29,383,813 |
| Irene E and George A Davis Foundation | Springfield | $26,945,016 |
| Broad Reach Foundation | Boston | $26,724,984 |
| State Street Foundation Inc | Boston | $25,496,290 |
| The Berkshire Taconic Community Foundation Inc | Sheffield | $25,442,434 |
| Essex County Community Fdn Inc | Beverly | $24,689,727 |
| Cri Foundation Inc | Boston | $23,065,892 |
| Hunt Street Fund Inc | Needham | $21,290,401 |
| Flatley Foundation | Braintree | $18,148,673 |
| Schooner Foundation | Boston | $17,575,111 |
| Hebrew Seniorlife Inc | Boston | $16,951,038 |
| Imago Dei Fund | Boston | $15,774,804 |
| Eastern Bank Charitable Foundation | Wakefield | $13,756,626 |
| Mac Five Foundation Inc | Lincoln | $13,640,081 |
| High Meadows Foundation | Boston | $12,035,020 |
| Amelia Peabody Charitable Fund Trs | Boston | $11,651,831 |
| Shipley Foundation Inc | Boston | $10,387,848 |
| Phillip and Susan Ragon Foundation | Cambridge | $10,027,163 |
| Flock Inc | Boston | $9,965,266 |
| Abrams Foundation Inc | Boston | $9,783,405 |
| Peter and Ann Lambertus Family Foundation Inc | Norwood | $9,426,539 |
| Yawkey Foundation II | Westwood | $8,581,203 |
| China Medical Board Inc | Cambridge | $8,199,765 |
| Wagner Foundation | Cambridge | $7,904,161 |
| Mathworks Foundation Inc | Natick | $6,825,775 |
| Lynch Foundation | Boston | $6,237,818 |
| Roux Family Foundation | Needham | $5,698,068 |
| Linde Family Foundation | Boston | $5,016,056 |
| Shapiro Foundation | Needham | $4,643,401 |
| Monkey King | Boston | $3,175,762 |
| Steven K and Winifred A Grinspoon Foundation | Agawam | $2,913,178 |
| Dunleavy Foundation | Boston | $2,738,768 |
| Cedar Tree Foundation Inc | Boston | $2,048,968 |
| Ann Theodore Foundation | Boston | $1,771,010 |
| Casey & Family Foundation | Boston | $970,523 |
| Massmutual Foundation Inc | Springfield | $820,000 |