| Tempus Unlimited Inc | Stoughton | $2,236,284,366 |
| World Federation of Hemophilia USA | Albany | $1,095,526,264 |
| American Heart Association Inc | Dallas | $1,070,192,712 |
| University Medical Center Management Corporaton | New Orleans | $792,867,500 |
| Central Arkansas Radiation Therapy Institute Inc | Little Rock | $620,523,795 |
| Barbara Ann Karmanos Cancer Hospital | Detroit | $606,826,459 |
| Devereux Foundation | Villanova | $507,919,260 |
| Can Community Health Inc | Tampa | $506,024,240 |
| Alzheimers Disease and Related Disorders Association Inc | Chicago | $457,244,898 |
| Lifespan Physician Group Inc | Providence | $366,760,724 |
| Blood Cancer United Inc | Washington | $358,698,504 |
| Cystic Fibrosis Foundation | Bethesda | $355,798,320 |
| H Lee Moffitt Cancer Center and Research Institute Inc | Tampa | $322,301,135 |
| Mary Bird Perkins Cancer Center | Baton Rouge | $318,045,658 |
| Maxaid | Seattle | $309,119,754 |
| Breakthrough t1d | New York | $301,723,973 |
| Dap Health Inc | Palm Springs | $280,264,706 |
| United Cerebral Palsy Associations of New York State Inc | New York | $274,118,557 |
| United Cerebral Palsy of New York City Inc | New York | $242,730,314 |
| Valley Childrens Medical Group | Madera | $211,413,193 |
| Stowers Resource Management Inc | Kansas City | $198,300,289 |
| C H M C Anesthesia Foundation Inc | Boston | $190,841,798 |
| H Lee Moffitt Cancer Ctr & Res Inst Life Time Cancer Scrn Ctr Inc | Tampa | $173,244,422 |
| Chase Brexton Health Services Inc | Baltimore | $172,818,534 |
| The Center for Discovery Inc | Harris | $171,818,211 |
| National Multiple Sclerosis Society | New York | $161,966,823 |
| American Society of Clinical Oncology | Alexandria | $159,100,585 |
| American Diabetes Association Inc | Arlington | $152,241,578 |
| American College of Radiology | Reston | $141,352,754 |
| Care Resource Community Health Centers Inc | Miami | $138,789,620 |
| American Academy of Pediatrics Inc | Itasca | $138,498,070 |
| American Cancer Society Inc | Atlanta | $136,826,348 |
| Miami Cancer Institute at Baptist Health Inc | Coral Gables | $132,288,902 |
| Amego Inc | Attleboro | $125,913,827 |
| American College of Cardiology Foundation | Washington | $125,831,256 |
| Center for Disability Services Inc | Albany | $125,771,990 |
| AIDS Arms Inc | Dallas | $124,939,996 |
| Upstate Cerebral Palsy Inc | Utica | $124,592,778 |
| Qsac Inc | NYC | $120,852,163 |
| Ehs Inc | Buffalo | $119,895,161 |
| American Lung Association | Chicago | $118,682,229 |
| Michigan Health Endowment Fund | Brighton | $116,075,631 |
| Childrens Anesthesiology Associates Ltd | Philadelphia | $115,647,675 |
| Washington Institute for Coagulation | Seattle | $112,675,357 |
| American Society of Hematology Inc | Washington | $112,402,449 |
| Vivent Health Inc | Milwaukee | $109,460,230 |
| American Board of Internal Medicine | Philadelphia | $108,351,701 |
| Cares Community Health | Sacramento | $105,005,933 |
| Susan G Komen Breast Cancer Foundation | Dallas | $103,154,379 |
| Fund for Public Health in New York Inc | New York | $98,316,171 |