| Trustees of the University of Pennsylvania | Philadelphia | $11,670,540,000 |
| University of Pittsburgh | Pittsburgh | $3,574,990,567 |
| Temple University-of the Commonwealth System of Higher Educ | Philadelphia | $1,787,499,000 |
| Thomas Jefferson University | Philadelphia | $1,581,285,779 |
| Drexel University | Philadelphia | $1,465,915,989 |
| Milton Hershey School & School Trust | Hershey | $1,262,623,043 |
| Villanova University | Villanova | $930,985,067 |
| Lehigh University | Bethlehem | $840,062,522 |
| Commonwealth Charter Academy Charter School | Harrisburg | $664,798,612 |
| Duquesne University of the Holy Spirit | Pittsburgh | $535,237,246 |
| Jefferson University Physicians | Philadelphia | $496,377,280 |
| Saint Josephs University | Philadelphia | $430,394,891 |
| Bucknell University | Lewisburg | $420,693,420 |
| Swarthmore College | Swarthmore | $382,192,696 |
| Lafayette College | Easton | $335,226,661 |
| Temple University Health System Inc | Philadelphia | $312,795,840 |
| Widener University | Chester | $294,909,738 |
| University of Scranton | Scranton | $294,074,987 |
| Bryn Mawr College | Bryn Mawr | $273,694,436 |
| Dickinson College | Carlisle | $266,152,779 |
| Community Services for Children Inc | Allentown | $255,493,861 |
| Gettysburg College | Gettysburg | $231,648,488 |
| Lake Erie College of Osteopathic Medicine Inc | Erie | $230,492,050 |
| Pennsylvania Cyber Charter School | Midland | $223,622,128 |
| Business Leadership Organized for Catholic Schools | Kng of Prussa | $213,597,549 |
| Corporation of Haverford College | Haverford | $212,487,281 |
| Franklin & Marshall College | Lancaster | $199,432,384 |
| Philadelphia College of Osteopathic Medicine | Philadelphia | $198,027,292 |
| Arcadia University | Glenside | $187,602,000 |
| Philadelphia University | Philadelphia | $178,538,248 |
| Uhf-Ca Gift Annuity Reserve Tr | Pittsburgh | $178,308,316 |
| Susquehanna University | Selinsgrove | $173,028,993 |
| Wilkes University | Wilkes Barre | $163,934,833 |
| Muhlenberg College | Allentown | $160,215,961 |
| Gannon University | Erie | $159,593,681 |
| Messiah University | Mechanicsburg | $155,424,073 |
| McElhattan Foundation | Pittsburgh | $152,882,594 |
| York College of Pennsylvania | York | $149,850,420 |
| Desales University | Center Valley | $149,674,851 |
| Mercyhurst University | Erie | $149,357,453 |
| Eastern University | St Davids | $146,831,434 |
| Allegheny College | Meadville | $139,329,636 |
| Lawschool Admissions Council Inc | Newtown | $133,588,322 |
| Ursinus College | Collegeville | $132,942,959 |
| Misericordia University | Dallas | $128,458,889 |
| Lebanon Valley College | Annville | $128,287,012 |
| Grove City College | Grove City | $124,522,482 |
| Reach Cyber Charter School | Enola | $120,808,316 |
| Marywood University | Scranton | $119,715,328 |
| Saint Vincent College | Latrobe | $119,006,596 |
| Juniata College | Huntingdon | $114,691,853 |
| La Salle University | Philadelphia | $113,358,327 |
| Agora Cyber Charter School Hope B Hague | King of Prussia | $109,451,977 |
| Elizabethtown College | Elizabethtown | $109,280,608 |
| Seton Hill University | Greensburg | $105,378,921 |
| Washington and Jefferson College | Washington | $103,719,125 |
| Saint Francis University | Loretto | $103,699,995 |
| Holy Family University | Philadelphia | $102,860,844 |
| Catherine Hershey Schools for Early Learning | Hershey | $99,251,064 |
| Carlow University | Pittsburgh | $98,195,281 |
| Chatham University | Pittsburgh | $97,788,713 |
| Kings College | Wilkes Barre | $95,731,184 |
| Chevron Phillips Chemical Co Lp Health & Benefit Tr Veba | Pittsburgh | $95,107,299 |
| Intealth | Philadelphia | $93,576,267 |
| Lincoln University | Lincoln Univ | $92,360,556 |
| Regents of the Mercersburg College | Mercersburg | $89,998,057 |
| Lycoming College | Williamsport | $87,407,769 |
| Mastery Schools of Camden Inc | Philadelphia | $87,139,072 |
| Albright College | Reading | $85,676,459 |
| Inspiritec Inc | Philadelphia | $83,423,745 |
| Episcopal Academy | Newtown Sq | $81,052,215 |
| The Harrisburg University of Science and Technology | Harrisburg | $80,148,800 |
| Neumann University | Aston | $79,133,274 |
| Collegium Charter School | Exton | $74,415,378 |
| Westminster College | New Wilmngtn | $74,236,079 |
| Central Pennsylvania Scholarship Fund | Tyrone | $73,854,376 |
| Gwynedd Mercy University | Gwynedd Vly | $72,210,000 |
| Archway Charter School of Chester Inc | Chester | $71,043,970 |
| Insight Pa Cyber Charter School | Exton | $70,180,285 |
| The Hill School | Pottstown | $66,765,203 |
| The Public School of Germantown | Ft Washington | $66,461,994 |
| Mastery Charter High School | Philadelphia | $65,445,727 |
| Pennsylvania Leadership Charter Schools | West Chester | $65,010,779 |
| Thiel College | Greenville | $62,529,246 |
| Immaculata University | Immaculata | $61,924,018 |
| Springside Chestnut Hill Academy | Philadelphia | $61,685,155 |
| Philadelphia Performing Arts A String Theory Charter School | Philadelphia | $60,893,660 |
| William Penn Charter School Inc | Philadelphia | $59,856,658 |
| Pennsylvania Virtual Charter School | Kng of Prussa | $59,530,781 |
| Geneva College | Beaver Falls | $58,329,803 |
| The Waynesburg University | Waynesburg | $57,842,211 |
| Cedar Crest College | Allentown | $57,462,091 |
| Shady Side Academy | Pittsburgh | $56,787,975 |
| Haverford School | Haverford | $55,818,766 |
| Chesnut Hill College of the Sisters of St Joseph | Philadelphia | $53,723,823 |
| Geisinger Commonwealth School of Medicine | Danville | $52,679,675 |
| Mount Aloysius College | Cresson | $50,030,266 |
| Carnegie Library of Pittsburgh | Pittsburgh | $48,193,926 |
| Malvern Preparatory School | Malvern | $48,105,970 |
| Lancaster Bible College | Lancaster | $47,366,909 |
| Academy of the New Church | Bryn Athyn | $45,587,386 |
| Shipley School | Bryn Mawr | $44,903,514 |
| First Philadelphia Preparatory Charter School | Philadelphia | $44,640,286 |
| Moore College of Art and Design | Philadelphia | $44,217,975 |
| Lackawanna College | Scranton | $43,176,752 |
| The Academy in Manayunk Inc | Conshohocken | $42,284,860 |
| Western Pennsylvania School for Blind Children | Pittsburgh | $41,912,974 |
| Mast Community Charter School II | Philadelphia | $41,838,962 |
| Agnes Irwin School | Rosemont | $40,741,583 |
| Lehigh Valley Academy Charter School | Bethlehem | $39,317,312 |
| Wilson College | Chambersburg | $39,054,589 |
| American College | Kng of Prussa | $38,659,573 |
| Western Pennsylvania School for the Deaf | Pittsburgh | $37,339,291 |
| Independence Mission Schools | Kng of Prussa | $36,510,515 |
| Overbrook School for the Blind | Philadelphia | $36,376,128 |
| University Student Housing | West Chester | $36,331,602 |
| Esperanza Academy Charter School | Philadelphia | $35,716,066 |
| The Childrens Institute of Pittsburgh | Pittsburgh | $25,865,631 |
| Foundation for Indiana University of Pennsylvania | Indiana | $25,494,777 |
| Williamson College of the Trades | Media | $24,826,905 |
| James Annenberg la Vea Charitable Foundation | Philadelphia | $18,535,222 |
| Cigna Foundation | Philadelphia | $15,548,109 |
| Cabrini University | Radnor | $446,766 |