| Christus Santa Rosa Health Care Corporation | $1,274,880,224 |
| Southwest Research Institute | $978,595,721 |
| Compass Connections | $448,681,852 |
| Somerset Academy Inc | $429,843,272 |
| Family Endeavors Inc | $408,185,445 |
| Barrio Comprehensive Family Health Care Center Inc | $397,405,153 |
| Trinity University | $350,520,667 |
| Methodist Healthcare Ministries of South Texas Inc | $312,051,463 |
| University of the Incarnate Word | $285,763,082 |
| Kate Marmion Charitable Foundation | $281,468,214 |
| San Antonio Food Bank Inc | $210,703,890 |
| St Marys University of San Antonio | $191,461,869 |
| Alamo Workforce Development Inc | $189,516,448 |
| Comprehensive Health Insurance Association | $171,726,054 |
| Riverwalk Education Foundation Inc | $150,696,334 |
| Great Hearts America-Texas | $148,570,155 |
| Qualtex Laboratories | $128,419,177 |
| Alamo Trust Inc | $115,314,343 |
| El Centro del Barrio Inc | $112,479,468 |
| Catholic Life Insurance | $109,863,065 |
| San Antonio Area Foundation | $108,029,836 |
| Goodwill Industries of San Antonio | $91,210,432 |
| Firstday Foundation | $85,638,191 |
| South Texas Blood & Tissue Center | $84,915,807 |
| Our Lady of the Lake University of San Antonio | $84,669,218 |
| Jubilee Academic Center Inc | $82,615,435 |
| Basis Texas Charter Schools Inc | $75,387,360 |
| Texas Biomedical Research Institute | $75,183,345 |
| Firstmark Credit Union | $71,306,267 |
| San Antonio Zoological Society Inc | $61,090,159 |
| Operation Homefront Inc | $55,582,313 |
| Compass Rose Education Inc | $52,799,561 |
| San Antonio Livestock Exposition Inc | $50,701,300 |
| Bio Bridge | $45,332,595 |
| United Way of San Antonio & Bexar County | $44,166,866 |
| Saint Marys Hall Inc | $40,833,623 |
| Morningside Ministries | $40,662,828 |
| Young Mens Christian Association of Greater San Antonio | $40,121,558 |
| Mays Family Foundation | $36,879,681 |
| Housing and Community Services Inc | $33,952,071 |
| Haven for Hope of Bexar County | $33,509,921 |
| Central Texas Regional Water Supply Corporation | $33,003,013 |
| Eula Mae and John Baugh Foundation | $31,413,924 |
| San Antonio Lighthouse for the Blind | $30,675,560 |
| Liftfund Inc | $30,110,957 |
| Bst Senior Living West Inc | $29,007,841 |
| Bcfs Health and Human Services | $28,615,731 |
| United Texas Credit Union | $23,949,852 |
| Robert J Kleberg Jr and Helen C Kleberg Foundation | $23,035,418 |
| Hermann Sons Life | $21,177,074 |
| Reach Resilience | $20,237,552 |
| Tom T East Sr & Alice K East & Alice H East & Robert C East Wildl | $16,451,180 |
| Ewing Halsell Foundation | $14,131,547 |
| Klesse Foundation | $12,523,003 |
| Charles Butt Foundation | $11,244,928 |
| Army Retirement Residence Supporting Foundation | $11,232,529 |
| Greehey Family Foundation | $8,931,125 |
| Tres Grace Family Foundation | $8,606,152 |
| The Usaa Foundation Inc | $8,456,521 |
| John L Santikos Charitable Foundation | $7,681,977 |
| Impetus Foundation | $7,635,616 |
| Harvey E Najim Charitable Foundation | $7,187,819 |
| p16plus Council of Greater Bexar County Foundation Inc | $3,905,095 |