| Memorial Hermann Health System | $8,563,610,095 |
| Methodist Hospital Group | $4,404,411,075 |
| The Methodist Hospital | $3,595,725,127 |
| Baylor College of Medicine | $2,979,794,649 |
| Community Health Choice Texas Inc | $1,905,542,999 |
| William Marsh Rice University | $1,635,701,788 |
| Community Health Choice Inc | $898,426,979 |
| Laura and John Arnold Foundation | $687,258,876 |
| Bakerripley | $635,358,695 |
| Harmony Public Schools | $609,931,274 |
| KIPP Texas Inc | $479,416,832 |
| Bp Corporation North America Inc Veba Master Trust | $459,807,777 |
| Legacy Community Health Services Inc | $453,793,852 |
| Houston Food Bank | $435,363,433 |
| Texas Dow Employees Credit Union | $357,942,346 |
| Memorial Hermann Medical Group | $354,699,745 |
| Schlumberger Master Health Care Trust | $337,522,299 |
| Yes Prep Public Schools Inc | $299,114,794 |
| Greater Houston Community Foundation | $293,284,617 |
| Museum of Fine Arts Houston | $255,296,660 |
| Houston Livestock Show & Rodeo Inc | $231,066,884 |
| Goodwill Industries of Houston | $224,604,694 |
| Brown Foundation Inc | $183,844,252 |
| Houston Christian University | $178,518,649 |
| First Community Credit Union | $167,373,815 |
| University of St Thomas | $154,920,338 |
| Methodist Hospital | $150,906,332 |
| Methodist Primary Care Group | $144,241,299 |
| Texas Medical Center | $141,502,264 |
| Gulf Coast Regional Blood Center | $132,655,313 |
| Memorial Hermann Pharmacy Services LLC | $130,290,986 |
| Houston Endowment Inc | $122,609,629 |
| Young Mens Christian Association of Greater Houston Area | $120,385,507 |
| St Johns School | $117,051,094 |
| Memorial Hermann Hospital Based Physician Group | $108,378,551 |
| Lifegift Organ Donation Center | $104,117,543 |
| Texas Medical Center Central Heat and Cooling Services Corp | $97,677,366 |
| Kinkaid School Inc | $96,476,669 |
| Catholic Charities of the Archdiocese of Galveston-Houston | $95,893,911 |
| First Service Credit Union | $91,080,564 |
| Episcopal Health Foundation | $88,717,449 |
| Houston Zoo Inc | $82,689,282 |
| Ila-West Gulf Maritime Association Inc Royalty Trust Fund No 1 | $80,788,249 |
| United Way of Greater Houston | $79,626,568 |
| The Awty International School | $72,542,072 |
| Kinder Foundation | $67,607,405 |
| Texas Bay Credit Union | $67,175,799 |
| The Menninger Clinic | $66,293,795 |
| Agreement of Trust for Maritime Association - Ila Welfare and Vaca | $63,544,240 |
| Memorial Hermann Foundation | $63,258,216 |
| Manned Space Flight Education Foundation Incorporated | $61,190,428 |
| Cenikor Foundation | $55,912,029 |
| More Than the Move Foundation | $51,995,278 |
| South Texas College of Law Houston Inc | $51,392,246 |
| St Hope Foundation Inc | $49,217,811 |
| Houston Museum of Natural Science | $48,430,467 |
| Smart Financial Credit Union | $47,907,359 |
| Methodist Hospital Self Insurance Trust | $47,812,082 |
| Robert A Welch Foundation 062491 | $47,618,127 |
| Members Choice Credit Union | $47,444,524 |
| Dan L Duncan Family Foundation | $46,632,137 |
| The Hobby Center Foundation | $46,189,489 |
| Ampp Global Center Inc | $44,631,316 |
| Lloyds Register North America Inc | $44,066,785 |
| Houston Country Club | $43,507,780 |
| Bph Holding Co Inc | $42,656,701 |
| Tejano Center for Community Concerns Inc | $42,225,647 |
| Houston Ballet Foundation | $41,957,306 |
| Buckingham Senior Living Community Inc | $37,598,799 |
| Menil Foundation Inc | $37,261,644 |
| River Oaks Country Club | $36,675,766 |
| Alley Theatre | $36,296,052 |
| Depelchin Childrens Center | $35,957,147 |
| Leducq Foundation for Cardiovascular Research | $34,809,129 |
| Centerpoint Energy Foundation Inc | $34,146,675 |
| John M Oquinn Foundation | $32,688,300 |
| Houston Jewish Community Foundation | $32,520,743 |
| Marvy Finger Family Foundation | $32,082,328 |
| Buffalo Bayou Partnership | $31,042,524 |
| Robert & Janice McNair Foundation | $30,532,379 |
| Dovetail Impact Foundation | $30,074,889 |
| Jerold B Katz Foundation | $29,643,222 |
| Ting Tsung and Wei Fong Chao Foundation | $28,005,470 |
| Houston Gateway Academy Inc | $27,901,991 |
| Scanlan Foundation | $25,182,271 |
| Texas Heart Institute | $24,749,411 |
| Apv Redevelopment Corporation | $24,619,447 |
| Terry Foundation | $23,941,988 |
| John P McGovern Foundation | $22,899,642 |
| The Powell Foundation | $22,834,407 |
| Shell USA Company Foundation | $19,020,102 |
| The Cullen Foundation | $18,825,483 |
| The Elkins Foundation | $16,766,495 |
| Energy Capital Credit Union | $15,703,673 |
| Albert and Margaret Alkek Foundation | $15,269,215 |
| Hamill Foundation | $15,104,349 |
| William Stamps Farish Fund | $14,115,418 |
| Cockrell Foundation | $10,617,553 |
| Wortham Foundation | $10,138,659 |
| Fondren Foundation | $10,028,544 |
| Jay Pritzker Foundation | $9,950,464 |
| Bp Foundation Inc | $8,522,984 |
| Simon Bolivar Foundation Inc | $7,817,067 |
| The Lanier Theological Library Foundation | $6,715,527 |
| Huffington Foundation | $6,337,922 |
| Hildebrand Foundation | $6,249,208 |
| Wayne Duddlesten Foundation | $2,848,957 |
| Hobby Family Foundation | $1,104,680 |
| The Stanford and Joan Alexander Foundation | $353,115 |