| Advanced Technology International | Summerville | $4,870,021,886 |
| Prisma Health - Upstate | Greenville | $3,605,252,123 |
| Prisma Health-Midlands | Greenville | $2,076,553,749 |
| Lexington Health Inc | West Columbia | $1,768,647,290 |
| Central Electric Power Cooperative Inc | Columbia | $1,607,586,867 |
| McLeod Regional Medical Center of the Pee Dee Inc | Florence | $1,494,230,490 |
| Prisma Health-University Medical Group | Greenville | $925,799,575 |
| Anmed Health | Anderson | $854,590,129 |
| St Francis Hospital Inc | Greenville | $850,947,341 |
| Bon Secours-St Francis Xavier Hospital Inc | Charleston | $620,583,353 |
| Berkeley Electric Cooperative Inc | Moncks Corner | $594,885,803 |
| The Blackbaud Giving Fund | Daniel Island | $545,823,387 |
| Roper Hospital Inc | Charleston | $539,462,922 |
| Apella Health Management Inc | Spartanburg | $524,676,090 |
| McLeod Loris Seacoast Hospital | Florence | $466,863,080 |
| Conway Hospital Inc | Conway | $416,525,532 |
| Prisma Health Medical Group-Midlands | Greenville | $401,120,303 |
| McLeod Health | Florence | $399,579,390 |
| Prisma Health | Greenville | $339,545,458 |
| Charter Institute at Erskine | Columbia | $299,875,169 |
| Furman University | Greenville | $296,850,871 |
| Georgetown Memorial Hospital | Georgetown | $268,144,649 |
| Georgetown Hospital System | Georgetown | $265,774,573 |
| Roper St Francis Healthcare | Ladson | $259,351,893 |
| Greenville Health Corporation | Greenville | $230,339,885 |
| Waccamaw Community Hospital | Georgetown | $225,726,056 |
| Horry Electric Cooperative Inc | Conway | $220,610,363 |
| Roper Saint Francis Physicians Network | Ladson | $212,953,585 |
| McLeod Physician Associates II | Florence | $210,087,905 |
| Blue Ridge Electric Cooperative | Pickens | $208,026,506 |
| Hopehealth Inc | Florence | $200,494,402 |
| Palmetto Electric Cooperative Inc | Ridgeland | $194,786,503 |
| Mid-Carolina Electric Cooperative Inc | Lexington | $179,489,833 |
| Anderson University | Anderson | $177,419,350 |
| Wofford College | Spartanburg | $166,390,074 |
| Laurens Electric Cooperative Inc | Laurens | $163,057,774 |
| Santee Electric Cooperative Inc | Kingstree | $156,282,282 |
| Roper St Francis Hospital-Berkeley Inc | Summerville | $152,118,799 |
| York Electric Cooperative Inc | York | $151,220,535 |
| The Blood Connection Incorporated | Piedmont | $149,672,688 |
| Aiken Electric Cooperative Inc | Aiken | $145,685,592 |
| Roper St Francis Mount Pleasant Hospital | Mt Pleasant | $139,653,117 |
| The Medical University of South Carolina Foundation | Charleston | $136,664,063 |
| Charleston Southern University | N Charleston | $125,239,964 |
| Clemson University Foundation | Clemson | $118,572,121 |
| Bju Inc | Greenville | $114,827,246 |
| Black River Electric Cooperative Inc | Sumter | $105,849,755 |
| McLeod Health Clarendon | Florence | $102,534,164 |
| Fairfield Electric Cooperative Inc | Blythewood | $99,865,183 |
| Welvista | Columbia | $95,953,350 |
| Lutheran Homes of South Carolina Inc | Irmo | $94,632,368 |
| Lowcountry Food Bank Inc | Charleston | $90,109,996 |
| McLeod Medical Center Dillon | Florence | $87,594,287 |
| Presbyterian Communities of South Carolina | Columbia | $87,552,673 |
| Caresouth Carolina Inc | Hartsville | $86,213,612 |
| University of South Carolina Educational Foundation | Columbia | $85,063,683 |
| McLeod Health Cheraw | Florence | $84,538,650 |
| Greater Myrtle Beach Collaborative | Myrtle Beach | $83,629,578 |
| Bishop Gadsden Episcopal Retirement Community | Charleston | $83,465,142 |
| Eau Claire Cooperative Health Center Inc | Columbia | $76,886,728 |
| Presbyterian College | Clinton | $76,670,174 |
| Genesis Healthcare Inc | Columbia | $76,259,788 |
| North Greenville University | Tigerville | $72,415,205 |
| South Carolina First Steps to School Readiness Board of Trustees | Columbia | $72,391,847 |
| Southern Mutual Church Insurance Company | Columbia | $71,997,103 |
| Iptay | Clemson | $71,552,779 |
| Columbia International University | Columbia | $71,013,416 |
| Edisto Electric Cooperative Inc | Bamberg | $69,615,546 |
| Claflin University | Orangeburg | $69,308,578 |
| Darla Moore and Richard Rainwater Foundation | Lake City | $68,195,128 |
| Newberry College | Newberry | $66,284,560 |
| Lynches River Electric Cooperative Inc | Pageland | $66,070,281 |
| Palmetto Goodwill | Charleston | $65,087,712 |
| Broad River Electric Cooperative Inc | Cowpens | $62,308,340 |
| Tri-County Electric Cooperative Inc | St Matthews | $61,964,736 |
| Goodwill Industries of Upstate Midlands South Carolina Inc | Greenville | $61,624,645 |
| Newberry Electric Cooperative Inc | Newberry | $58,676,656 |
| South Carolina Student Loan Corporation | Columbia | $58,364,992 |
| Bluecross Blueshield of South Carolina Foundation | Columbia | $57,929,618 |
| Charleston Educational Excellence Financing Corporation | Charleston | $57,341,944 |
| National Wild Turkey Federation Inc | Edgefield | $54,333,787 |
| Benedict College | Columbia | $52,764,064 |
| We Are Sharing Hope Sc | Charleston | $52,297,016 |
| Converse University | Spartanburg | $50,688,632 |
| Spartanburg County Foundation | Spartanburg | $50,610,860 |
| Kuznik Charitable Foundation | Charleston | $48,484,551 |
| South Carolina Episcopal Home at Still Hopes | West Columbia | $48,124,967 |
| Erskine College | Due West | $47,967,931 |
| Central Carolina Community Foundation | Columbia | $47,127,019 |
| Meeting Street Schools | Charleston | $46,778,434 |
| Limestone University | Gaffney | $46,519,696 |
| Coastal Community Foundation of South Carolina Inc | N Charleston | $46,328,098 |
| National Council of Examiners for Engineering and Surveying | Greenville | $45,696,211 |
| University of South Carolina School of Medicine Educational Trust | Columbia | $44,237,810 |
| Christ Church Episcopal School | Greenville | $44,124,234 |
| Peace Center Foundation | Greenville | $41,873,432 |
| Little River Electric Cooperative Inc | Abbeville | $39,237,867 |
| Citadel Foundation | Charleston | $37,924,388 |
| Community Foundation of Greenville Inc | Greenville | $37,550,064 |
| St Francis Physician Services Inc | Greenville | $36,888,174 |
| Radio Training Network Inc | Greenville | $36,327,263 |
| Inspirational Network Inc | Indian Land | $35,338,832 |
| YMCA of Greenville | Greenville | $29,834,081 |
| Securing Assets for Education | Moncks Corner | $26,810,615 |
| Upstate Senior Living Inc | Greenville | $26,546,216 |
| Leroy Springs & Company Inc | Fort Mill | $24,121,610 |
| Scago Educational Facilities Corporation for Pickens School Dis | Easley | $22,003,623 |
| Hollingsworth Funds Inc | Greenville | $18,619,297 |
| Spc Credit Union | Hartsville | $18,337,189 |
| Medical Society of S C | Charleston | $17,721,491 |
| Building Equity Sooner for Tomarrow | Greenville | $14,194,205 |
| United States Endowment Forforestry and Communities Inc | Greenville | $10,178,279 |
| Movement Resources | Fort Mill | $4,052,708 |
| Beemok Family Foundation | Charleston | $3,874,618 |