| Case Western Reserve University | $1,735,353,050 |
| Jack Joseph and Morton Mandel Foundation | $929,693,588 |
| Southwest General Health Center | $449,561,763 |
| The Cleveland Foundation | $302,815,178 |
| Jack Joseph and Morton Mandel Supporting Foundation | $168,250,145 |
| Gateway Economic Development Corporation of Greater Cleveland | $162,797,089 |
| Jewish Federation of Cleveland | $150,540,330 |
| Hospice of the Western Reserve Inc | $100,511,212 |
| Greater Cleveland Food Bank Inc | $99,223,738 |
| Playhouse Square Foundation | $89,145,681 |
| United Church Insurance Association | $87,827,463 |
| Cleveland Museum of Art | $84,403,647 |
| The Musical Arts Association | $78,823,318 |
| Catholic Charities Corporation | $66,774,146 |
| Rock and Roll Hall of Fame and Museum Inc | $57,541,431 |
| Chn Housing Partners | $57,282,070 |
| Emerald Development and Economic | $56,254,776 |
| George Gund Foundation | $51,521,913 |
| Cleveland Institute of Art | $46,109,243 |
| Medical Center Company | $44,015,704 |
| Imagine Schools Inc | $41,618,296 |
| United Church Insurance Company Inc | $41,429,752 |
| Lifebanc | $39,226,937 |
| Cleveland Institute of Music | $32,974,445 |
| Cleveland Museum of Natural History | $31,637,866 |
| Cleveland-Cliffs Steel LLC Veba Trust | $31,403,786 |
| Catholic Community Foundation | $30,956,507 |
| Keybank Foundation | $28,145,113 |
| Euclid Avenue Development Corporation | $25,961,412 |
| The McGregor Foundation | $24,680,352 |
| 151 Firefighters Community Credit Union Inc | $20,259,225 |
| 715 Pse Credit Union Inc | $19,534,332 |
| Progressive Insurance Foundation | $15,487,259 |
| Kelvin and Eleanor Smith Foundation | $9,697,575 |
| Parker-Hannifin Foundation | $9,074,288 |
| Saint Lukes Foundation of Cleveland Ohio | $8,125,078 |
| The@Joseph and Florence Mandel Family Foundation-Michele M and | $7,499,360 |
| Joseph & Florence Mandel Family Foundation - Weinberg Family Fund | $7,471,619 |