| Henry Ford Health System | $5,284,200,687 |
| Blue Care Network of Michigan | $4,804,963,335 |
| Health Alliance Plan of Michigan | $1,636,128,583 |
| Henry Ford Health St John Hospital | $1,135,239,182 |
| Henry Ford Health Providence Hospital | $1,013,288,101 |
| Wa Foote Memorial Hospital | $907,585,199 |
| Henry Ford Macomb Hospital Corporation | $651,632,688 |
| Barbara Ann Karmanos Cancer Hospital | $606,826,459 |
| Henry Ford Health Macomb Oakland Hospital | $496,217,205 |
| Henry Ford Wyandotte Hospital Corporation | $470,255,911 |
| Henry Ford Health Genesys Hospital | $388,243,218 |
| Michigan Conference of Teamsters Welfare Fund | $367,748,029 |
| Henry Ford Health Rochester Hospital | $298,242,396 |
| Community Foundation for Southeast Michigan | $246,111,003 |
| University of Detroit Mercy | $191,402,646 |
| University Physician Group | $156,383,459 |
| United Way for Southeastern Michigan | $112,317,221 |
| Wayne-Metropolitan Community Action Agency | $108,988,362 |
| University Pediatricians | $108,299,011 |
| Detroit Area Agency on Aging | $107,362,068 |
| Samaritas | $106,378,070 |
| College for Creative Studies | $97,259,458 |
| Gleaners Community Food Bank of Southeastern Michigan | $93,598,866 |
| The Ralph C Wilson Jr Foundation | $89,392,039 |
| Detroit Institute of Arts | $85,952,461 |
| Detroit Employment Solutions Corporation | $72,561,677 |
| Research Foundation for the City University of New York | $62,965,087 |
| Henry Ford Semi Medical Group | $51,579,603 |
| Detroit Athletic Club | $47,273,566 |
| American Lightweight Materials Manufacturing Innovation Institute | $42,468,343 |
| Henry Ford Medical Group Genesys | $40,024,777 |
| Detroit Riverfront Conservancy Inc | $38,859,268 |
| Detroit Symphony Orchestra Hall Inc | $38,553,756 |
| Gilbert Fam Foundation | $38,521,985 |
| Invest Detroit Foundation | $32,419,547 |
| St John Providence | $32,059,546 |
| Credit Unions Chartered in the State of Michigan | $30,579,992 |
| Wayne State University | $27,859,948 |
| Barbara Ann Karmanos Cancer Institute | $27,111,385 |
| Mount Elliott Cemetery | $26,521,429 |
| Skillman Foundation | $21,945,374 |
| Henry Ford Health System Foundation | $9,508,342 |
| Homeless Action Network of Detroit | $8,787,756 |
| McGregor Fund | $5,095,165 |
| Dte Energy Foundation | $4,503,774 |
| Hudson-Webber Foundation | -$5,122,872 |