| Northwestern Memorial Healthcare | $11,241,795,455 |
| University of Chicago | $5,617,072,703 |
| Central States Southeast & Southwest Areas Health & Welfare F | $5,468,051,502 |
| Feeding America | $5,001,395,215 |
| University of Chicago Medical Center | $3,573,895,376 |
| Northwestern Memorial Healthcare | $2,773,030,061 |
| Rush University Medical Center | $2,758,712,727 |
| The Chicago Community Trust | $2,143,553,763 |
| Ann & Robert H Lurie Childrens Hospital of Chicago | $1,726,489,572 |
| Alliant Credit Union | $1,266,937,770 |
| The Johnson & Johnson Voluntary Employee Benefit Trust | $1,203,786,930 |
| Loyola University of Chicago | $1,058,054,182 |
| Accenture United States Benefit | $1,022,690,877 |
| Depaul University | $966,926,889 |
| Blue Cross Blue Shield Association | $862,659,881 |
| John D & Catherine T Macarthur Foundation | $613,786,298 |
| Builders Initiative | $519,855,780 |
| Rehabilitation Institute of Chicago | $481,384,946 |
| Mount Sinai Hospital Medical Center | $481,329,620 |
| Art Institute of Chicago | $464,393,130 |
| Alzheimers Disease and Related Disorders Association Inc | $457,244,898 |
| Illinois Institute of Technology | $448,541,928 |
| Lurie Childrens Medical Group Inc | $434,004,131 |
| Chicago District Council of Carpenters Welfare Fund | $432,802,350 |
| National Opinion Research Center | $397,190,163 |
| National Association of Realtors | $360,812,686 |
| Exelon Corporation Employees Benefit Trust | $345,734,529 |
| International Fellowship of Christians & Jews | $318,221,645 |
| Jewish Federation of Metropolitan Chicago | $284,591,607 |
| Rush System for Health | $283,154,871 |
| United States Soccer Federation Inc | $268,051,647 |
| Columbia College Chicago | $267,562,634 |
| Greater Chicago Food Depository | $241,580,413 |
| American Dental Association | $237,080,024 |
| Caterpillar Inc Group Insurance Master Trust Agreement | $235,178,939 |
| Hunter Family Foundation | $234,140,854 |
| Noble Network of Charter Schools | $230,347,701 |
| Hyatt Corporation Welfare Benefit Trust | $221,731,602 |
| Howard Brown Health Center | $217,487,912 |
| The Barack Obama Foundation | $209,759,915 |
| National Council of Young Mens Christian Assns of the USA | $198,431,455 |
| Pipe Fitters Welfare Fund Local 597 | $195,778,777 |
| Beatrice P Delaney Char Fdn | $195,568,689 |
| United Airlines Pilot Retiree Health Account Plan | $191,240,933 |
| The Brinson Foundation | $183,594,091 |
| Misericordia Home | $182,367,259 |
| Metropolitan Family Services | $180,243,830 |
| Institute for the International Education of Students | $178,488,153 |
| American College of Surgeons | $177,470,920 |
| Catholic Charities of the Archdiocese of Chicago | $174,675,811 |
| Community and Economic Development Association of Cook County Inc | $168,111,516 |
| American Bar Association | $166,167,244 |
| Humboldt Park Health | $166,088,712 |
| Access Community Health Network | $165,645,419 |
| Thorek Memorial Hospital | $160,965,453 |
| Saint Anthony Hospital | $158,997,124 |
| Zell Family Foundation | $158,353,230 |
| Arie and Ida Crown Memorial | $155,180,049 |
| St Bernard Hospital | $154,997,327 |
| Jewish United Fund of Metropolitan Chicago | $154,199,770 |
| Cushing Family Foundation | $152,055,068 |
| SEIU Healthcare Il Home Care & Child Care Fund | $149,997,885 |
| American Hospital Association Inc | $146,713,516 |
| Roosevelt University | $145,744,413 |
| SEIU Local 1 & Participating Employers Health Trust | $145,615,805 |
| The Chicago School - California Inc | $144,160,010 |
| National Council of State Boards of Nursing Inc | $143,984,750 |
| The Thresholds | $137,560,763 |
| Holy Cross Hospital | $137,327,552 |
| Saint Xavier University | $136,723,892 |
| Ronald McDonald House Global | $134,535,982 |
| McGaw Medical Center of Northwestern University | $134,384,711 |
| Chicago Charter School Foundation | $133,999,480 |
| Erie Family Health Center Inc | $132,295,957 |
| Moody Bible Institute of Chicago | $129,574,445 |
| Chicago Symphony Orchestra | $125,909,695 |
| Acero Charter Schools Inc | $119,122,514 |
| American Lung Association | $118,682,229 |
| Gateway Foundation Inc | $118,229,702 |
| National Board of YMCA Employee Benefit Trust | $117,718,475 |
| Start Early | $115,249,579 |
| Field Museum of Natural History | $114,814,441 |
| Sinai Health System | $112,479,570 |
| United Brotherhood of Carpenters & Joiners of America | $110,028,389 |
| Robert R McCormick Foundation | $105,305,792 |
| Mount Sinai Community Foundation | $105,145,970 |
| North Park University | $102,582,608 |
| American Bar Association Fund for Justice and Education | $102,362,062 |
| Shedd Aquarium Society | $101,974,802 |
| Lawndale Christian Health Center | $97,565,268 |
| Union Health Service Inc | $96,063,386 |
| Jackson Park Hospital Foundation | $95,796,032 |
| La Rabida Childrens Hospital | $93,423,720 |
| Envision Unlimited | $92,646,589 |
| Plumbers Welfare Fund-130 U A | $92,550,851 |
| International Union of Operating Engineers Local 399 | $89,928,420 |
| Accreditation Council for Graduate Medical Education | $88,540,135 |
| One Hope United | $87,672,686 |
| Lawndale Educational and Regional Network Charter School | $87,443,895 |
| Childrens Home & Aid Society of Illinois | $85,729,842 |
| National Equity Fund Inc | $85,480,265 |
| Spencer Foundation | $81,530,805 |
| Crown Family Foundation | $80,975,305 |
| Lyric Opera of Chicago | $80,826,148 |
| YMCA of Metropolitan Chicago | $80,477,142 |
| Nef Community Investments Inc | $80,447,261 |
| Tcs Education System | $80,006,956 |
| Easter Seals Metropolitan Chicago Inc | $78,391,883 |
| American Property Casualty Insurance Association | $77,845,711 |
| Chicago Cook Workforce Partnership | $77,702,139 |
| Loretto Hospital | $75,631,689 |
| Ucan | $74,558,540 |
| Navy Pier Inc | $74,554,644 |
| Esperanza Health Centers | $69,086,476 |
| Heartland Human Care Services Inc | $68,808,814 |
| Alpha Kappa Alpha Sorority Inc | $67,595,271 |
| Kenneth C Griffin Museum of Science and Industry | $66,431,592 |
| Stanley Manne Childrens Research Institute | $65,057,786 |
| Muscular Dystrophy Association | $64,160,032 |
| Joyce Foundation | $63,765,035 |
| Ukraine-Moldova American Enterprise Fund | $63,044,607 |
| Klaff Family Foundation | $62,897,228 |
| Council for Jewish Elderly | $62,703,406 |
| Iff | $62,525,991 |
| Planned Parenthood of Illinois | $62,315,745 |
| Elks National Foundation Inc | $61,768,710 |
| Latin School of Chicago | $61,074,655 |
| Elevate Energy | $60,915,201 |
| Misericordia Foundation | $59,437,046 |
| Benevolent & Protective Order of Elks of the USA | $57,388,257 |
| Chicago Cred Inc | $56,990,213 |
| Illinois Coalition for Immigrant and Refugee Rights | $56,337,333 |
| Francis W Parker School | $56,151,021 |
| Paul M Angell Family Foundation | $54,980,497 |
| Big Shoulders Fund | $53,155,887 |
| Schwab Rehabilitation Hosptial and Care Network | $52,714,409 |
| Opportunity International Inc | $51,137,074 |
| Adler University | $50,681,925 |
| Lincoln Park Zoological Society | $50,519,973 |
| Window to the World Communications Inc | $50,411,662 |
| After School Matters Inc | $48,377,490 |
| Alpha Kappa Alpha Sorority Inc | $47,694,836 |
| Easter Seals Inc | $47,513,200 |
| United Way of Metropolitan Chicago Inc | $47,075,947 |
| Paws Chicago | $46,965,874 |
| Polish National Alliance of the United States of North America | $45,573,316 |
| Circle of Service Foundation | $45,496,219 |
| Illinois College of Optometry | $45,393,261 |
| Alliance for Clinical Trials in Oncology Foundation | $44,527,686 |
| Youth Guidance | $44,260,936 |
| University of Chicago Self Insurance Trust | $44,175,679 |
| Jewish Child and Family Services | $42,403,196 |
| Intrinsic Schools | $42,172,445 |
| Society of Thoracic Surgeons | $42,114,448 |
| United Food & Commercial Workers Union Local 1546 Health & Welfare | $41,862,022 |
| American Library Association | $40,436,015 |
| International Brotherhood of Teamsters Health & Welfare Fd | $39,630,389 |
| Academy of Nutrition and Dietetics | $39,595,449 |
| Polish Roman Catholic Union of America | $39,474,542 |
| Childrens Hospital of Chicago Medical Center | $39,221,947 |
| Primecare Community Health Inc | $37,814,772 |
| Exelon Corporation Employees Benefit Trust for Union Employees | $36,402,093 |
| Pritzker Foundation | $36,193,620 |
| American Osteopathic Association | $35,774,516 |
| Chicago Public Media Inc | $35,621,838 |
| Chicago School of Professional Psychology Inc | $35,543,648 |
| Pepco Holdings Inc Veba Trust | $34,443,318 |
| Erikson Institute | $33,422,139 |
| American Health Information Management Association | $32,550,697 |
| American Bar Endowment | $30,399,177 |
| Admiral at the Lake | $30,306,959 |
| University of Western States | $29,118,608 |
| Onegoal | $28,815,119 |
| Museum of Contemporary Art | $25,003,137 |
| Community Investment Corp | $24,834,893 |
| Full Circle Communities Inc | $24,235,261 |
| Imc Chicago Charitable Foundation | $24,198,334 |
| Conduit Foundation | $23,304,184 |
| Childrens Memorial Hospital Self | $22,383,325 |
| Jfmc Facilities Corporation | $22,232,129 |
| Michael Reese Health Trust | $21,519,197 |
| Emerson Elec Charitable Trust | $20,800,942 |
| Coleman Foundation Inc | $20,533,923 |
| Pritzker Traubert Foundation | $19,719,134 |
| Steans Family Foundation | $19,229,441 |
| Accenture Foundation Inc | $19,199,448 |
| First Northern Credit Union | $18,808,616 |
| Frank E Payne and Seba B Payne Foundation | $17,217,145 |
| Jewel Nail Bomar Trust 8336230300 | $16,232,482 |
| Tawani Charitable Distribution Fund | $15,689,197 |
| The Walsh Foundation | $15,685,193 |
| Colorado Park 277 Corporation | $15,143,859 |
| Peoples Support Foundation Limited | $15,083,694 |
| Bluhm Family Charitable Foundation | $14,929,839 |
| Trott Family Philanthropies Inc | $14,401,070 |
| Reva & David Logan Foundation | $14,377,846 |
| Wisconsin Energy Corporation Union Retiree Medical Benefits Trust | $14,053,244 |
| Motorola Solutions Foundation | $13,797,250 |
| Vicinity Credit Union | $13,283,274 |
| Mansueto Foundation | $13,148,678 |
| Blue Cross and Blue Shield Plans National Retiree Health Benefits | $12,870,688 |
| Polk Bros Foundation Inc | $12,187,684 |
| Richard L Duchossois Memorial Foundation | $11,484,765 |
| Tull Fam Foundation | $11,313,500 |
| Booth Ferris Foundation | $11,046,105 |
| Alsam Foundation | $9,385,297 |
| Alphawood Foundation | $9,136,910 |
| The Richard H Driehaus Foundation | $8,835,016 |
| Canning Foundation | $8,332,723 |
| Wilemal Fund | $8,303,096 |
| Dauten Family Foundation | $8,254,309 |
| Frechette Family Foundation | $7,240,512 |
| Lloyd A Fry Foundation | $5,688,272 |
| The Pritzker Pucker Family Foundation | $5,444,283 |
| Antonio J Gracias Family Foundation Inc | $4,862,228 |
| Pritzker Family Foundation | $4,180,922 |
| Tr Parkside Towers Corp | $4,070,788 |
| Anthony Pritzker Fam Foundation | $3,914,238 |
| Foglia Family Foundation | $3,869,381 |
| The Bobolink Foundation | $3,736,007 |
| Fulk Family Foundation Inc | $3,703,610 |
| Anahata Foundation | $3,124,355 |
| The Duchossois Family Foundation | $3,053,045 |
| Scanlan Family Foundation | $1,853,775 |
| Serr Charitable Action Tr Uw 09242002 | $1,680,471 |
| Chicagobeyond Inc | $500,000 |
| Terra Foundation for American Art | $449,057 |
| Exelon Foundation | $353,401 |
| The Irving Harris Foundation | -$8,935,456 |