| Southern Baptist Hospital of Florida Inc | $2,969,280,739 |
| The Nemours Foundation | $2,357,991,833 |
| Shands Jacksonville Medical Center Inc | $1,334,760,134 |
| State Chartered Credit Unions in Florida | $886,102,117 |
| Step Up for Students - Florida Inc | $859,413,209 |
| University of Florida Jacksonville Physicians Inc | $520,451,299 |
| Alfred I Dupont Charitable Trust | $498,778,461 |
| Dechomai Foundation Inc | $494,612,669 |
| Dechomai Asset Trust | $459,598,859 |
| Wounded Warrior Project Inc | $431,679,370 |
| Baptist Health System Inc | $289,140,667 |
| Baptist Medical Center Beaches | $243,535,698 |
| Jacksonville University | $227,501,878 |
| Brooks Rehabilitation Hospital | $192,800,290 |
| State Chartered Credit Unions in Florida | $171,954,625 |
| C Herman and Mary Virginia Terry | $159,645,729 |
| Baptist Medical Center of Nassau I Nc | $146,587,047 |
| Community Hospice of Northeast Florida Inc | $146,516,161 |
| The Community Foundation for Northeast Florida Inc | $112,310,767 |
| Early Learning Coalition of Duval Inc | $98,650,586 |
| Episcopal Childrens Services Inc | $90,460,915 |
| Family Support Services of North Florida Inc | $85,490,437 |
| Regional Food Bank of Northeast Florida Inc | $78,108,404 |
| State Chartered Credit Unions in Florida | $77,010,017 |
| Bolles School | $76,989,032 |
| Naval Continuing Care Retirement Foundation Inc | $65,952,244 |
| Baptist Health System Foundation Inc | $62,633,341 |
| Pace Center for Girls Inc | $62,222,656 |
| River City Education Services | $58,964,716 |
| The Young Mens Christian Association of Floridas First | $58,646,372 |
| Patriot Services Group Inc | $57,253,936 |
| Genesis Health Inc | $56,411,158 |
| Goodwill Industries of North Florida Inc | $55,812,809 |
| Florida Proton Therapy Institute Inc | $53,051,165 |
| Jacksonville Zoological Society Inc | $50,606,141 |
| Affordable Housing Preservation Corporation | $41,717,546 |
| United Way of Northeast Florida Inc | $25,954,027 |
| The University of North Florida Foundation Inc | $24,467,193 |
| Jessie Ball Dupont Religious Charitable & Educational Fund | $18,056,396 |
| Blue Cross and Blue Shield of Florida Foundation Inc | -$1,508,267 |