| Christiana Care Health Services Inc | Wilmington | $3,368,541,741 |
| American Online Giving Foundation Inc | Newark | $2,503,754,849 |
| University of Delaware | Newark | $1,689,371,610 |
| Bayhealth Medical Center Inc | Dover | $1,262,135,519 |
| Beebe Medical Center Inc | Lewes | $672,214,901 |
| Delaware State University | Dover | $275,459,558 |
| Delaware Electric Cooperative Inc | Greenwood | $257,934,054 |
| Tidalhealth Nanticoke Inc | Seaford | $245,972,911 |
| The Linux Foundation | Wilmington | $220,730,594 |
| Union Hospital of Cecil County | Wilmington | $199,132,581 |
| American Gift Fund | Wilmington | $166,326,352 |
| Shelby Cullom Davis Charitable Fund Inc | Wilmington | $143,676,662 |
| St Francis Hospital Inc | Wilmington | $142,444,869 |
| Wilmington University Inc | New Castle | $142,357,658 |
| Five Pointe Professional Liability Insurance Company | Wilmington | $129,405,688 |
| Essex Avenue Foundation | Wilmington | $114,892,724 |
| The Grateful Lives Foundation | Wilmington | $84,765,909 |
| Conexio Care Inc | Claymont | $81,035,277 |
| Unidel Foundation Inc | Greenville | $80,958,548 |
| Tessitura Network Inc | Middletown | $67,865,978 |
| Henry Francis Du Pont Winterthur Museum Inc | Winterthur | $63,522,418 |
| Beebe Physican Network Inc | Lewes | $62,126,534 |
| Goodwill Industries of Delaware & Delaware County Inc | Wilmington | $59,171,791 |
| Young Mens Christian Association of Delaware | Wilmington | $58,557,537 |
| Delaware Community Foundation | Wilmington | $58,240,621 |
| The Barry S Sternlicht Foundation | Wilmington | $56,909,462 |
| Sustainable Energy Utility Inc | Dover | $48,748,802 |
| Zearn | Claymont | $48,442,804 |
| St Andrews School of Delaware Inc | Middletown | $46,589,197 |
| Odyssey Charter School Incorporated | Wilmington | $45,917,008 |
| Food Bank of Delaware Inc | Newark | $45,436,074 |
| The Monarch Charitable Foundation | Wilmington | $40,361,997 |
| Moccasin Lake Foundation | Wilmington | $39,340,549 |
| Tower Hill School | Wilmington | $38,165,652 |
| Easter Seals Delaware & Marylands Eastern Shore Inc | New Castle | $37,229,468 |
| Goldey Beacom College Inc | Wilmington | $34,153,353 |
| Aspira of Delaware Charter Operations | Newark | $32,851,155 |
| Lytton-Kambara Foundation | Wilmington | $31,220,698 |
| Morgridge Family Foundation | Wilmington | $29,584,556 |
| Longwood Foundation Inc | Wilmington | $28,715,921 |
| Adobe Foundation | Wilmington | $27,750,518 |
| The Champlin Foundation | Wilmington | $23,809,561 |
| John & Tami Marick Foundation Inc | Wilmington | $22,599,363 |
| La Vida Feliz Foundation | Wilmington | $16,269,884 |
| Mt Cuba Center Inc | Hockessin | $15,937,225 |
| Ge Li & Ning Zhao Family Foundation | Wilmington | $15,840,148 |
| Robert and Ardis James Foundation Inc | Wilmington | $13,975,536 |
| Erik E and Edith H Bergstrom Foundation A Charitable Trust | Wilmington | $12,990,841 |
| Three Sisters Foundation | Wilmington | $12,919,392 |
| Aurora Foundation | Wilmington | $12,238,545 |
| Moise Y Safra Foundation Inc | Wilmington | $11,265,299 |
| Wasily Family Foundation | Wilmington | $10,561,958 |
| Workday Foundation | Wilmington | $8,488,565 |
| Lisa Dean Moseley Foundation | Rockland | $7,206,561 |
| Louis and Anne Abrons Foundation Inc | Wilmington | $6,739,442 |
| American Electric Power Foundation | Wilmington | $5,857,994 |
| Frank McHugh-Odonovan Foundation Inc | Wilmington | $5,399,944 |
| Filecoin Foundation for the Decentralized Web | Middletown | $1,962,290 |
| Jps Peace Love & Happiness Foundation | Wilmington | $1,879,557 |
| Abbas Storehouse Foundation | Wilmington | $1,169,179 |
| Ssp International Inc | Wilmington | $962,702 |
| Fund for Policy Reform | Wilmington | $0 |