| University of Denver | $875,422,584 |
| Saint Joseph Hospital | $645,390,055 |
| Denver Health Medical Plan Inc | $536,017,809 |
| University of Colorado Foundation | $456,087,334 |
| National Jewish Health | $375,353,154 |
| Denver Foundation | $208,259,786 |
| Regis University | $182,539,610 |
| Mental Health Center of Denver | $146,201,550 |
| Denver School of Science and Technology Inc | $137,680,069 |
| Credit Unions Chartered in the State of Colorado | $135,792,779 |
| Daniels Fund | $123,024,315 |
| Colorado Coalition for the Homeless | $108,772,300 |
| The Colorado Health Foundation | $103,581,780 |
| Strive Preparatory Schools | $102,571,668 |
| Rocky Mountain Human Services | $100,190,126 |
| Denver Dumb Friends League | $92,897,062 |
| Denver Center for the Performing Arts | $89,341,492 |
| Denver Art Museum Inc | $87,033,570 |
| Energy Outreach Colorado | $84,974,563 |
| Colorado Health Benefit Exchange | $72,273,797 |
| Donor Alliance Inc | $71,594,779 |
| American Indian College Fund | $66,504,283 |
| Denver Zoological Foundation Inc | $66,039,623 |
| Rocky Mountain Planned Parenthood Inc | $61,957,279 |
| Anschutz Foundation | $57,962,545 |
| The Colorado Museum of Natural History | $57,234,971 |
| Colorado Academy | $54,221,616 |
| Caring for Denver Foundation | $53,380,023 |
| Denver Rescue Mission | $52,957,488 |
| Western Stock Show Association | $49,810,409 |
| The American University of Paris Inc | $49,636,435 |
| Pipe Industry Insurance Fund | $48,213,157 |
| Rose Community Foundation | $47,965,197 |
| Mercy Housing Inc | $46,466,606 |
| Denver Metro Convention & Visitors Bureau | $46,293,630 |
| Catholic Charities and Community Services of the Archdiocese of Den | $44,937,049 |
| p3 Foundation Inc | $39,643,717 |
| Hospice of Metro Denver Incorporated | $38,210,365 |
| Mercy Housing California | $37,570,015 |
| Association of Operating Room Nurses Inc | $35,255,349 |
| Gates Family Foundation | $29,077,917 |
| Nurse Family Partnership | $28,694,523 |
| Colorado Trust | $28,418,812 |
| Credit Unions Chartered in the State of Colorado | $28,277,616 |
| Boettcher Foundation | $19,026,629 |
| Temple Hoyne Buell Foundation | $17,419,429 |
| Urban Peak Denver | $15,459,346 |
| Louis Calder Foundation | $11,695,845 |
| Adolph Coors Foundation | $9,584,061 |
| Nextfifty Initiative | $9,574,875 |
| Zoma Foundation | $7,139,327 |
| Sturm Family Foundation | $5,907,526 |
| Jgl Foundation | $4,070,064 |
| Gary Philanthropy | $3,702,813 |
| Gill Foundation | $2,982,029 |