| Scripps Health | $5,134,555,653 |
| Sharp Healthcare | $2,192,680,289 |
| Rady Childrens Hospital San Diego | $1,762,087,501 |
| Sharp Memorial Hospital | $1,653,101,506 |
| Southern California Schools Voluntary Employees Benefits Assoc | $1,206,757,001 |
| Sharp Health Plan | $1,199,323,529 |
| Grossmont Hospital Corporation | $1,132,662,700 |
| San Diego Imperial Counties Developmental Services Inc | $993,496,415 |
| University of San Diego | $741,185,768 |
| Sharp Chula Vista Medical Center | $714,814,717 |
| Centro de Salud de la Comunidad de San Ysidro Inc | $615,881,926 |
| Scripps Health Plan Services Inc | $585,050,495 |
| National University | $555,848,700 |
| Family Health Centers of San Diego Inc | $488,260,631 |
| San Diego Zoo Wildlife Alliance | $437,607,695 |
| San Diego County Credit Union | $423,032,905 |
| YMCA of San Diego County | $371,820,304 |
| Center for Sustainable Energy | $335,556,775 |
| San Diego State University Foundation | $247,529,653 |
| Health Quality Partners of Southern California | $205,707,381 |
| Point Loma Nazarene University | $200,343,026 |
| The San Diego Foundation | $196,946,092 |
| Sharp Coronado Hospital and Healthcare Center | $195,318,498 |
| Jewish Community Foundation of San Diego | $194,237,199 |
| Petco Animal Supplies Stores Inc Group Benefit Plan and Trust | $190,983,596 |
| Credit Unions in the State of California | $167,593,351 |
| Community Eldercare of San Diego | $156,112,375 |
| The Neighborhood House Assn | $130,446,549 |
| Planned Parenthood of the Pacific Southwest | $128,944,128 |
| Community Research Foundation Inc | $116,176,086 |
| La Maestra Family Clinic Inc | $112,395,961 |
| High Tech High | $112,387,405 |
| Jacobs & Cushman San Diego Food Bank | $110,962,770 |
| Mental Health Systems Inc | $100,506,644 |
| Catholic Charities Diocese of San Diego | $99,121,061 |
| Aztec Shops Ltd | $94,475,818 |
| Goodwill Industries of San Diego County | $94,330,630 |
| Jewish Family Service of San Diego | $93,143,304 |
| Avid Center | $86,402,327 |
| Job Options Inc | $71,814,211 |
| Casa de las Campanas Inc | $69,291,200 |
| St Vincent de Paul Village Inc | $68,146,405 |
| San Diego Humane Society and SPCA | $67,557,221 |
| Francis Parker School | $65,642,120 |
| San Diego City Employees Retiree Medical Trust | $63,271,711 |
| Campanile Foundation | $62,298,004 |
| San Diego Blood Bank | $52,907,163 |
| Credit Unions in the State of | $52,021,404 |
| San Diego Symphony Orchestra Association | $50,686,168 |
| California Western School of Law | $45,105,610 |
| St Pauls Episcopal Home Inc | $42,009,583 |
| Cdc Small Business Finance Corp | $41,499,674 |
| Uss Midway Museum | $39,443,527 |
| New Alternatives Incorporated | $34,156,594 |
| Rady Childrens Hospital Foundation San Diego | $31,046,590 |
| My Point Credit Union | $30,712,664 |
| Cabrillo Credit Union | $27,350,587 |
| S V D P Management Inc | $26,342,231 |
| Wheelhouse Credit Union | $23,540,529 |
| Irving and Elanor Jaffee Foundation Inc | $18,568,820 |
| Community Housing Works | $18,484,067 |
| Torrey Coast Foundation | $12,857,718 |
| Conrad Prebys Foundation | -$58,066,159 |