| Glaxosmithkline Patient Access Programs Foundation | Philadelphia | $881,930,422 |
| Donald B and Dorothy L Stabler Foundation | Camp Hill | $159,509,613 |
| William Penn Foundation | Philadelphia | $152,349,810 |
| John Templeton Foundation | West Conshohocken | $126,807,051 |
| Hillman Family Foundations | Pittsburgh | $83,393,067 |
| Pnc Foundation | Pittsburgh | $82,865,128 |
| The Heinz Endowments | Pittsburgh | $48,689,957 |
| Sarah Scaife Foundation Inc | Pittsburgh | $45,183,180 |
| The Comcast Nbcuniversal Foundation | Philadelphia | $44,915,397 |
| McCune Foundation | Pittsburgh | $42,730,959 |
| J E Barbey 8 Tenacre Foundation | Pittsburgh | $41,721,944 |
| Beth and Ravenel Curry Foundation | Erie | $35,131,750 |
| Snider Foundation | Collegeville | $35,050,768 |
| Colcom Foundation | Pittsburgh | $23,101,275 |
| I Am Mercy Foundation | Haverford | $21,769,434 |
| Jack Buncher Foundation | Pittsburgh | $21,278,555 |
| Allegheny Foundation | Pittsburgh | $20,526,962 |
| Dicks Sporting Goods Foundation | Coraopolis | $19,598,968 |
| Neubauer Family Foundation | Philadelphia | $19,482,813 |
| Wyncote Foundation | Philadelphia | $17,166,730 |
| Posner Foundation of Pittsburgh | Pittsburgh | $17,092,753 |
| Maguire Foundation | West Conshohocken | $16,514,829 |
| Connelly Foundation | W Cnshohocken | $15,776,059 |
| Cigna Foundation | Philadelphia | $15,648,243 |
| Claude Worthington Benedum Foundation | Pittsburgh | $15,343,808 |
| Highmark Foundation | Pittsburgh | $13,762,385 |
| Eden Hall Foundation | Pittsburgh | $12,960,141 |
| Hamilton Family Charitable Trust | Wayne | $12,955,497 |
| Seed the Dream Foundation | Gladwyne | $11,816,217 |
| E Rhodes and Leona B Carpenter Foundation | Wayne | $11,598,861 |
| The Thomas R Kline Foundation | Philadelphia | $11,513,382 |
| The Powder Mill Foundation | York | $11,329,365 |
| The McCausland Foundation | Lafayette Hl | $11,295,634 |
| Lor Foundation Inc | West Chester | $11,238,059 |
| Grable Foundation | Pittsburgh | $11,134,456 |
| Susquehanna Foundation | Bala Cynwyd | $10,960,054 |
| Zachary Smith Reynolds Trust | Pittsburgh | $10,264,707 |
| James Annenberg la Vea Charitable Foundation | Philadelphia | $10,235,966 |
| Dunn Foundation | Collegeville | $10,077,000 |
| Independence Public Media of Philadelphia Inc | Philadelphia | $9,842,200 |
| Arthur N Rupe Foundation | West Chester | $9,617,149 |
| Arete Foundation | Philadelphia | $9,450,007 |
| Air Products Foundation | Allentown | $9,435,120 |
| Shear Family Foundation Inc | Pittsburgh | $9,086,800 |
| Ppg Industries Foundation | Pittsburgh | $9,066,003 |
| Lincoln Financial Foundation Inc | Radnor | $8,622,311 |
| Independence Blue Cross Foundation | Philadelphia | $8,466,130 |
| Daniel B and Florence E Green Foundation | Conshohocken | $8,444,000 |
| The Steinman Foundation | Lancaster | $8,162,879 |
| The Aileen K and Brian L Roberts Foundation | Philadelphia | $7,982,424 |
| The Sigety Family Foundation Inc | Pipersville | $7,909,689 |
| Howmet Aerospace Foundation | Pittsburgh | $7,626,787 |
| Chubb Charitable Foundation | Philadelphia | $7,415,847 |
| Community Care and Development Corporation | Bala Cynwyd | $7,391,100 |
| Leslie Miller and Richard Worley Foundation | Bryn Mawr | $7,357,380 |
| Alexander Grass Foundation | Mechanicsburg | $7,194,500 |
| High Foundation | Lancaster | $6,804,139 |
| McElhattan Foundation | Pittsburgh | $6,080,217 |
| Andrea W and Kenneth C Frazier Family Foundation | Philadelphia | $4,886,030 |
| Scott Foundation Inc | Greensburg | $1,445,561 |
| Louis J Mascaro Foundation Inc | Audubon | $900,000 |
| Longwood Gardens Inc | Kennett Square | $439,702 |