| Jack Joseph and Morton Mandel Foundation | Cleveland | $257,875,136 |
| The Wexner Family Charitable Fund | New Albany | $91,171,558 |
| Farmer Family Foundation | Cincinnati | $44,058,309 |
| John J & Mary R Schiff Foundation | Cincinnati | $40,999,886 |
| Nationwide Foundation | Columbus | $39,892,322 |
| George Gund Foundation | Cleveland | $29,601,792 |
| Keybank Foundation | Cleveland | $28,153,952 |
| Connor Group Foundation | Miamisburg | $25,345,381 |
| Jewish Foundation of Cincinnati | Cincinnati | $23,108,108 |
| Huntington Foundation | Columbus | $21,308,323 |
| Fifth Third Union Trust Co Foundation | Cincinnati | $17,499,231 |
| Robert and Adele Schiff Family Foundation Inc | Cincinnati | $15,738,400 |
| Timken Foundation of Canton | Canton | $15,426,400 |
| Osteopathic Heritage Foundation | Dublin | $14,408,461 |
| Jay and Jeanie Schottenstein Foundation | Columbus | $14,195,423 |
| Mathile Family Foundation | Dayton | $13,465,775 |
| The Lozick Family Foundation | Pepper Pike | $12,742,684 |
| Austin E Knowlton Foundation Inc | Cincinnati | $12,204,256 |
| Joseph & Florence Mandel Family Foundation - Weinberg Family Fund | Cleveland | $10,904,571 |
| The Carl H and Edyth B Lindner Foundation | Cincinnati | $10,456,295 |
| Ruth J and Robert A Conway Foundation Inc | Cincinnati | $9,746,010 |
| Kelvin and Eleanor Smith Foundation | Cleveland | $9,733,500 |
| Nord Family Foundation | Amherst | $9,724,318 |
| Western & Southern Financial Fund Inc | Cincinnati | $9,420,265 |
| The@Joseph and Florence Mandel Family Foundation-Michele M and | Cleveland | $8,317,793 |
| Nordson Corporation Foundation | Westlake | $8,100,029 |
| Ag Foundation | East Liverpool | $8,099,644 |
| Eaton Charitable Fund | Brooklyn | $8,080,087 |
| Hcs Foundation | Westlake | $8,051,841 |
| Parker-Hannifin Foundation | Cleveland | $7,845,021 |
| Albert J Weatherhead Estate Trust Uw Item IV National City Bk of Cle | Mayfield Hts | $7,697,221 |
| Nisource Charitable Foundation | Columbus | $7,647,661 |
| Wilson Sheehan Foundation | Springfield | $7,593,890 |
| Saint Lukes Foundation of Cleveland Ohio | Cleveland | $7,554,000 |
| James J and Joan A Gardner Family Foundation | Cincinnati | $7,500,000 |
| Progressive Insurance Foundation | Cleveland | $7,387,491 |
| Veale Foundation | Pepper Pike | $7,342,850 |
| Geoffrey Gund Foundation | Brooklyn | $7,325,000 |
| Gar Foundation | Akron | $7,223,231 |
| Greenacres Foundation | Cincinnati | $6,951,629 |