| Fidelity Foundation | Boston | $146,970,213 |
| Popplestone Foundation | Boston | $145,306,337 |
| Barr Foundation | Boston | $106,878,904 |
| Klarman Family Foundation | Boston | $89,989,220 |
| The Patrick J McGovern Foundation Inc | Boston | $65,777,146 |
| The Grantham Foundation for the Protection of the Environment | Boston | $61,346,003 |
| The Morningside Foundation | Newton Centre | $59,827,608 |
| one8 Foundation | Boston | $56,036,140 |
| Liberty Mutual Foundation Inc | Boston | $52,239,174 |
| Phillip and Susan Ragon Foundation | Cambridge | $51,434,770 |
| Adelson Family Foundation | Needham | $43,806,189 |
| Flatley Foundation | Braintree | $36,618,882 |
| Dr Miriam and Sheldon G Adelson Medical Research Foundation | Needham | $35,217,204 |
| Casey & Family Foundation | Boston | $30,858,949 |
| Growald Climate Fund Inc | Brookline | $28,245,496 |
| Cummings Foundation Grants Inc | Woburn | $26,113,917 |
| State Street Foundation Inc | Boston | $25,779,865 |
| Tjx Foundation Inc | Framingham | $23,322,493 |
| Champions of Love Foundation Inc | Boston | $22,265,090 |
| Edward C Johnson Fund | Boston | $22,016,479 |
| Yawkey Foundation II | Westwood | $18,990,047 |
| Cummings Foundation Inc | Woburn | $18,366,000 |
| Richard and Susan Smith Family Foundation | Newton | $18,325,319 |
| Peter and Ann Lambertus Family Foundation Inc | Norwood | $14,657,500 |
| Cedar Tree Foundation Inc | Boston | $13,492,844 |
| Wagner Foundation | Cambridge | $13,196,500 |
| Roux Family Foundation | Needham | $12,792,000 |
| Imago Dei Fund | Boston | $12,688,035 |
| The Jaket Foundation | Boston | $12,384,798 |
| Eastern Bank Charitable Foundation | Wakefield | $12,002,250 |
| Dunleavy Foundation | Boston | $12,000,000 |
| Shapiro Foundation | Needham | $11,094,363 |
| George I Alden Trust | Worcester | $11,023,000 |
| Dentaquest Partnership for Oral Health Advancement Inc | Boston | $10,972,159 |
| Steven K and Winifred A Grinspoon Foundation | Agawam | $10,727,653 |
| Shipley Foundation Inc | Boston | $10,515,314 |
| Richard K Lubin Family Foundation | Boston | $10,121,486 |
| Mathworks Foundation Inc | Natick | $9,850,000 |
| Massmutual Foundation Inc | Springfield | $9,817,000 |
| Schooner Foundation | Boston | $9,646,986 |
| The Paul and Phyllis Fireman Charitable Foundation | Waltham | $9,630,500 |
| Kraft Family Foundation Inc | Foxborough | $9,572,269 |
| Linde Family Foundation | Boston | $9,189,210 |
| William J & Lia G Poorvu Family Foundation | Cambridge | $8,831,000 |
| Vertex Foundation Inc | Boston | $8,773,667 |
| Hunt Street Fund Inc | Needham | $8,643,802 |
| Amelia Peabody Charitable Fund Trs | Boston | $8,561,000 |
| Mac Five Foundation Inc | Lincoln | $8,494,500 |
| China Medical Board Inc | Cambridge | $8,488,736 |
| Broad Reach Foundation | Boston | $8,470,000 |
| High Meadows Foundation | Boston | $8,422,500 |
| Jenzabar Foundation Inc | Boston | $8,402,565 |
| Ann Theodore Foundation | Boston | $8,210,693 |
| Irene E and George A Davis Foundation | Springfield | $8,185,642 |
| Perfect Seas Foundation Inc | Boston | $8,000,000 |
| Monkey King | Boston | $7,872,168 |
| Lynch Foundation | Boston | $7,723,164 |
| Gordon Gund and Llura Liggett Gund 1993 Charitable Foundation | Concord | $7,712,833 |
| Abrams Foundation Inc | Boston | $7,656,666 |
| Flock Inc | Boston | $7,461,616 |
| The Robert and Michelle Cooke Atchinson Foundation | Winchester | $5,212,600 |
| Micah Philanthropies | Agawam | $4,395,583 |
| Jerome Lyle Rappaport Charitable Foundation | Burlington | $2,973,112 |
| Cri Foundation Inc | Boston | $2,722,256 |
| Blue Square Alliance Against Hate Corp | Foxborough | $850,000 |
| Cardinal Brook Trust | Boston | $24,625 |