| Battelle Memorial Institute | Columbus | $13,526,408,187 |
| Advanced Technology International | Summerville | $4,870,021,886 |
| The Mitre Corporation | Bedford | $2,475,879,129 |
| Aerospace Corporation | Chantilly | $1,623,067,000 |
| Research Triangle Institute | Rtp | $1,254,259,534 |
| Alliance for Energy Innovation LLC | Golden | $1,064,585,917 |
| Southwest Research Institute | San Antonio | $978,595,721 |
| Charles Stark Draper Laboratory Inc | Cambridge | $949,348,102 |
| American Chemical Society | Washington | $819,099,460 |
| Noblis Inc | Reston | $614,468,693 |
| Association of Universities for | Washington | $468,809,827 |
| Sri International | Menlo Park | $437,926,151 |
| National Academy of Sciences | Washington | $361,712,009 |
| Climateworks Foundation | San Francisco | $350,641,228 |
| Institute for Defense Analyses | Alexandria | $344,675,047 |
| Woods Hole Oceanographic Institution | Woods Hole | $344,338,772 |
| University Corporation for Atmospheric Research | Boulder | $288,690,542 |
| Alfred E Mann Foundation for Scientific Research | Santa Clarita | $257,887,615 |
| Southeastern Universities Research Association Inc | Washington | $251,855,977 |
| Medical Technology Enterprise Consortium | N Bethesda | $234,472,156 |
| Cold Spring Harbor Laboratory | Cold Spg Hbr | $232,693,889 |
| University of Kansas Center for Research Inc | Lawrence | $220,648,490 |
| American Type Culture Collection | Manassas | $198,027,310 |
| Prepass Safety Alliance | Phoenix | $196,625,833 |
| Internet Corporation for Assigned Names and Numbers | Los Angeles | $194,948,725 |
| Salk Institute for Biological Studies | La Jolla | $181,393,442 |
| The Hawaii Pacific Foundation Inc | Honolulu | $173,736,286 |
| Fermi Research Alliance LLC | Batavia | $168,510,542 |
| Associated Universities Inc | Vienna | $145,098,658 |
| Analytic Services Inc | Arlington | $142,473,079 |
| American Society of Mechanical Engineers | New York | $136,989,570 |
| National Advanced Mobility Consortium | Ann Arbor | $135,705,794 |
| American Society for Testing and Materials | Conshohocken | $134,694,228 |
| American Association for the Advancement of Science | Washington | $129,476,881 |
| Institute of Gas Technology | Des Plaines | $124,247,894 |
| National Center for Defense Manufacturing and Machining | Johnstown | $119,433,940 |
| Mriglobal | Kansas City | $115,849,749 |
| Carnegie Institution of Washington | Washington | $106,544,070 |
| Public Interest Registry | Reston | $106,377,555 |
| American Physical Society | College Park | $106,332,062 |
| Concurrent Technologies Corporation | Johnstown | $101,274,766 |
| Association for Computing Machinery Inc | New York | $96,182,576 |
| Sae International | Warrendale | $95,057,958 |
| American Institute of Physics Incorporated | College Park | $92,366,805 |
| Society for Science and the Public | Washington | $91,128,420 |
| Institute for Advanced Study | Princeton | $88,930,858 |
| For Inspiration and Recognition of Science and Technology First | Manchester | $84,935,359 |
| University Corporation for Advanced Internet Development | Ann Arbor | $81,580,045 |
| Schmidt Ocean Institute | Palo Alto | $78,308,682 |
| McNc | R Triangle Park | $74,135,271 |