| good360 | Alexandria | $3,264,744,236 |
| Gavi Alliance | Washington | $2,547,417,284 |
| Direct Relief | Santa Barbara | $2,398,998,642 |
| Americares Foundation Inc | Stamford | $1,851,063,617 |
| World Vision | Federal Way | $1,423,305,144 |
| Map International | Brunswick | $1,379,040,410 |
| International Rescue Committee Inc | New York | $1,314,041,795 |
| Save the Children Federation Inc | Fairfield | $920,455,828 |
| United States Fund for UNICEF | New York | $835,217,861 |
| Cooperative for Assistance and Relief Everywhere Inc | Atlanta | $832,911,696 |
| Plan International Inc | New York | $779,465,250 |
| Medecins Sans Frontieres USA Inc | New York | $776,922,926 |
| Family Health International | Durham | $539,608,705 |
| World Economic Forum | New York | $528,837,504 |
| American Jewish Joint Distribution Committee Inc | New York | $412,907,647 |
| Food for the Poor Inc | Coconut Creek | $412,105,034 |
| Feed the Children Inc | Oklahoma City | $386,446,959 |
| Mercy Corps | Portland | $376,251,780 |
| Habitat for Humanity International Inc | Atlanta | $370,010,910 |
| Carter Center Collaborative Inc | Atlanta | $367,877,415 |
| One Acre Fund | Highland Park | $351,753,463 |
| United Israel Appeal Inc | New York | $350,481,992 |
| Heart to Heart International Inc | Lenexa | $347,317,501 |
| World Central Kitchen Incorporated | Washington | $327,840,221 |
| Catholic Medical Mission Board Inc | New York | $326,399,389 |
| Project Orbis International Inc | New York | $323,437,845 |
| Path | Seattle | $321,942,685 |
| Institute of International Education Inc | New York | $306,381,946 |
| Global Impact | Washington | $290,357,767 |
| Church World Service Inc | Elkhart | $279,865,803 |
| Matthew 25 Ministries Inc | Blue Ash | $279,440,386 |
| American Committee for the Weizmann Institute of Science Inc | New York | $262,912,000 |
| Mercy Ships International | Lindale | $250,375,032 |
| Clinton Health Access Initiative Inc | Boston | $246,122,771 |
| International Medical Corps | Los Angeles | $235,323,065 |
| Centro Internacional de Mejoramiento de Maiz Y Trigo | Alexandria | $220,531,073 |
| Childrens Hunger Fund | Rnch Cascades | $215,110,859 |
| World Resources Institute | Washington | $213,044,770 |
| Childfund International USA | Richmond | $210,435,038 |
| World Relief Corporation O National | Baltimore | $205,941,236 |
| Myriad USA Inc | New York | $200,540,834 |
| Jewish National Fund -Keren Kayemeth Leisrael- Inc | Rockville Ctr | $197,058,808 |
| Kyle J and Sharon Krause Family Foundation | Des Moines | $184,647,900 |
| Friends of the Israel Defense Forces | New York | $182,806,815 |
| Dkt International Inc | Washington | $182,329,221 |
| American Near East Refugee Aid Inc | Washington | $176,317,328 |
| The Carter Center Inc | Atlanta | $163,882,063 |
| Acdi Voca | Washington | $162,518,399 |
| Heifer Project International | Little Rock | $162,027,025 |
| Action Against Hunger USA | New York | $160,756,238 |