| Organization | City | Revenue |
|---|
| Prisma Health - Upstate | Greenville | $3,605,252,123 |
| Prisma Health-Midlands | Greenville | $2,076,553,749 |
| Lexington Health Inc | West Columbia | $1,768,647,290 |
| McLeod Regional Medical Center of the Pee Dee Inc | Florence | $1,494,230,490 |
| Prisma Health-University Medical Group | Greenville | $925,799,575 |
| Anmed Health | Anderson | $854,590,129 |
| Bon Secours-St Francis Xavier Hospital Inc | Charleston | $620,583,353 |
| Roper Hospital Inc | Charleston | $539,462,922 |
| McLeod Loris Seacoast Hospital | Florence | $466,863,080 |
| Conway Hospital Inc | Conway | $416,525,532 |
| McLeod Health | Florence | $399,579,390 |
| Prisma Health | Greenville | $339,545,458 |
| Georgetown Memorial Hospital | Georgetown | $268,144,649 |
| Georgetown Hospital System | Georgetown | $265,774,573 |
| Roper St Francis Healthcare | Ladson | $259,351,893 |
| Greenville Health Corporation | Greenville | $230,339,885 |
| Waccamaw Community Hospital | Georgetown | $225,726,056 |
| Roper Saint Francis Physicians Network | Ladson | $212,953,585 |
| McLeod Physician Associates II | Florence | $210,087,905 |
| Hopehealth Inc | Florence | $200,494,402 |
| Roper St Francis Hospital-Berkeley Inc | Summerville | $152,118,799 |
| The Blood Connection Incorporated | Piedmont | $149,672,688 |
| Roper St Francis Mount Pleasant Hospital | Mt Pleasant | $139,653,117 |
| McLeod Health Clarendon | Florence | $102,534,164 |
| Welvista | Columbia | $95,953,350 |
| McLeod Medical Center Dillon | Florence | $87,594,287 |
| Caresouth Carolina Inc | Hartsville | $86,213,612 |
| McLeod Health Cheraw | Florence | $84,538,650 |
| Genesis Healthcare Inc | Columbia | $76,259,788 |
| South Carolina Episcopal Home at Still Hopes | West Columbia | $48,124,967 |
| St Francis Physician Services Inc | Greenville | $36,888,174 |
| Medical Society of S C | Charleston | $17,721,491 |